PUBLICATIONS

  1. Moore, EM, Maestas, DR Jr, Cherry, CC, Garcia, JA, Comeau, HY, Davenport Huyer, L et al.. Biomaterials direct functional B cell response in a material-specific manner. Sci Adv. 2021;7 (49):eabj5830. doi: 10.1126/sciadv.abj5830. PubMed PMID:34851674 .
  2. Wan, M, Gray-Gaillard, EF, Elisseeff, JH. Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration. Bone Res. 2021;9 (1):41. doi: 10.1038/s41413-021-00164-y. PubMed PMID:34508069 PubMed Central PMC8433460.
  3. Cherry, C, Maestas, DR, Han, J, Andorko, JI, Cahan, P, Fertig, EJ et al.. Computational reconstruction of the signalling networks surrounding implanted biomaterials from single-cell transcriptomics. Nat Biomed Eng. 2021;5 (10):1228-1238. doi: 10.1038/s41551-021-00770-5. PubMed PMID:34341534 .
  4. Wang, X, Chung, L, Hooks, J, Maestas, DR Jr, Lebid, A, Andorko, JI et al.. Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing. Sci Adv. 2021;7 (16):. doi: 10.1126/sciadv.abe2635. PubMed PMID:33863719 PubMed Central PMC8051883.
  5. Tsai, HW, Lina, I, Motz, KM, Chung, L, Ding, D, Murphy, MK et al.. Glutamine Inhibition Reduces Iatrogenic Laryngotracheal Stenosis. Laryngoscope. 2021;131 (7):E2125-E2130. doi: 10.1002/lary.29385. PubMed PMID:33433011 PubMed Central PMC8205976.
  6. Faust, HJ, Zhang, H, Han, J, Wolf, MT, Jeon, OH, Sadtler, K et al.. IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis. J Clin Invest. 2020;130 (10):5493-5507. doi: 10.1172/JCI134091. PubMed PMID:32955487 PubMed Central PMC7524483.
  7. Batshon, G, Elayyan, J, Qiq, O, Reich, E, Ben-Aderet, L, Kandel, L et al.. Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence. Ann Rheum Dis. 2020;79 (10):1370-1380. doi: 10.1136/annrheumdis-2020-217072. PubMed PMID:32665267 PubMed Central PMC7509530.
  8. Moore, EM, Maestas, DR Jr, Comeau, HY, Elisseeff, JH. The Immune System and Its Contribution to Variability in Regenerative Medicine. Tissue Eng Part B Rev. 2021;27 (1):39-47. doi: 10.1089/ten.TEB.2019.0335. PubMed PMID:32635878 PubMed Central PMC7891216.
  9. He, Y, Zhang, X, Chang, J, Kim, HN, Zhang, P, Wang, Y et al.. Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. Nat Commun. 2020;11 (1):1996. doi: 10.1038/s41467-020-15838-0. PubMed PMID:32332723 PubMed Central PMC7181703.
  10. Chung, L, Maestas, DR Jr, Lebid, A, Mageau, A, Rosson, GD, Wu, X et al.. Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans. Sci Transl Med. 2020;12 (539):. doi: 10.1126/scitranslmed.aax3799. PubMed PMID:32295900 PubMed Central PMC7219543.
  11. Wang, X, Majumdar, S, Soiberman, U, Webb, JN, Chung, L, Scarcelli, G et al.. Multifunctional synthetic Bowman's membrane-stromal biomimetic for corneal reconstruction. Biomaterials. 2020;241 :119880. doi: 10.1016/j.biomaterials.2020.119880. PubMed PMID:32097748 PubMed Central PMC7236884.
  12. Tan, Y, Suarez, A, Garza, M, Khan, AA, Elisseeff, J, Coon, D et al.. Human fibroblast-macrophage tissue spheroids demonstrate ratio-dependent fibrotic activity for in vitro fibrogenesis model development. Biomater Sci. 2020;8 (7):1951-1960. doi: 10.1039/c9bm00900k. PubMed PMID:32057054 PubMed Central PMC7179997.
  13. Wolf, MT, Elisseeff, JH. The Canary in the Coal Mine: Biomaterial Implants to Monitor Cancer Recurrence. Cancer Res. 2020;80 (3):377-378. doi: 10.1158/0008-5472.CAN-19-3631. PubMed PMID:32015156 .
  14. DeParis, SW, Zhu, AY, Majumdar, S, Tian, J, Elisseeff, J, Jun, AS et al.. Effects of collagen crosslinking on porcine and human tarsal plate. BMC Ophthalmol. 2019;19 (1):255. doi: 10.1186/s12886-019-1254-3. PubMed PMID:31842794 PubMed Central PMC6915903.
  15. Gabriel, J, Brennan, D, Elisseeff, JH, Beachley, V. Microarray Embedding/Sectioning for Parallel Analysis of 3D Cell Spheroids. Sci Rep. 2019;9 (1):16287. doi: 10.1038/s41598-019-52007-w. PubMed PMID:31705048 PubMed Central PMC6841729.
  16. Sommerfeld, SD, Cherry, C, Schwab, RM, Chung, L, Maestas, DR Jr, Laffont, P et al.. Interleukin-36γ-producing macrophages drive IL-17-mediated fibrosis. Sci Immunol. 2019;4 (40):. doi: 10.1126/sciimmunol.aax4783. PubMed PMID:31604843 PubMed Central PMC7549193.
  17. Yin, H, Wang, X, Majumdar, S, Sohn, J, Kim, BJ, Stark, W et al.. Tissue-Derived Biological Particles Restore Cornea Properties in an Enzyme-Mediated Corneal Ectatic Model. Bioengineering (Basel). 2019;6 (4):. doi: 10.3390/bioengineering6040090. PubMed PMID:31569699 PubMed Central PMC6956048.
  18. Sadtler, K, Elisseeff, JH. Analyzing the scaffold immune microenvironment using flow cytometry: practices, methods and considerations for immune analysis of biomaterials. Biomater Sci. 2019;7 (11):4472-4481. doi: 10.1039/c9bm00349e. PubMed PMID:31424059 .
  19. Jeon, OH, Wilson, DR, Clement, CC, Rathod, S, Cherry, C, Powell, B et al.. Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers. JCI Insight. 2019;4 (7):. doi: 10.1172/jci.insight.125019. PubMed PMID:30944259 PubMed Central PMC6483636.
  20. Duvvuri, M, Motz, K, Murphy, M, Feeley, M, Ding, D, Lee, A et al.. Engineering an immunomodulatory drug-eluting stent to treat laryngotracheal stenosis. Biomater Sci. 2019;7 (5):1863-1874. doi: 10.1039/c8bm01623b. PubMed PMID:30874257 PubMed Central PMC6478537.
  21. Wolf, MT, Ganguly, S, Wang, TL, Anderson, CW, Sadtler, K, Narain, R et al.. A biologic scaffold-associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy. Sci Transl Med. 2019;11 (477):. doi: 10.1126/scitranslmed.aat7973. PubMed PMID:30700576 PubMed Central PMC7254933.
  22. Elisseeff, J. Biomaterials Science Emerging Investigators 2019. Biomater Sci. 2019;7 (2):454-460. doi: 10.1039/c8bm90065e. PubMed PMID:30666328 .
  23. Yin, H, Lu, Q, Wang, X, Majumdar, S, Jun, AS, Stark, WJ et al.. Tissue-derived microparticles reduce inflammation and fibrosis in cornea wounds. Acta Biomater. 2019;85 :192-202. doi: 10.1016/j.actbio.2018.12.027. PubMed PMID:30579044 .
  24. Sadtler, K, Wolf, MT, Ganguly, S, Moad, CA, Chung, L, Majumdar, S et al.. Divergent immune responses to synthetic and biological scaffolds. Biomaterials. 2019;192 :405-415. doi: 10.1016/j.biomaterials.2018.11.002. PubMed PMID:30500722 .
  25. Majumdar, S, Wang, X, Sommerfeld, SD, Chae, JJ, Athanasopoulou, EN, Shores, LS et al.. Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants. Adv Funct Mater. 2018;28 (41):. doi: 10.1002/adfm.201804076. PubMed PMID:34531709 PubMed Central PMC8442673.
  26. Wolf, MT, Zhang, H, Sharma, B, Marcus, NA, Pietzner, U, Fickert, S et al.. Two-Year Follow-Up and Remodeling Kinetics of ChonDux Hydrogel for Full-Thickness Cartilage Defect Repair in the Knee. Cartilage. 2020;11 (4):447-457. doi: 10.1177/1947603518800547. PubMed PMID:30280586 PubMed Central PMC7488951.
  27. Faust, HJ, Sommerfeld, SD, Rathod, S, Rittenbach, A, Ray Banerjee, S, Tsui, BMW et al.. A hyaluronic acid binding peptide-polymer system for treating osteoarthritis. Biomaterials. 2018;183 :93-101. doi: 10.1016/j.biomaterials.2018.08.045. PubMed PMID:30149233 .
  28. Estrellas, KM, Chung, L, Cheu, LA, Sadtler, K, Majumdar, S, Mula, J et al.. Biological scaffold-mediated delivery of myostatin inhibitor promotes a regenerative immune response in an animal model of Duchenne muscular dystrophy. J Biol Chem. 2018;293 (40):15594-15605. doi: 10.1074/jbc.RA118.004417. PubMed PMID:30139748 PubMed Central PMC6177591.
  29. Liu, H, Zhou, Z, Lin, H, Wu, J, Ginn, B, Choi, JS et al.. Synthetic Nanofiber-Reinforced Amniotic Membrane via Interfacial Bonding. ACS Appl Mater Interfaces. 2018;10 (17):14559-14569. doi: 10.1021/acsami.8b03087. PubMed PMID:29613762 .
  30. Jeon, OH, David, N, Campisi, J, Elisseeff, JH. Senescent cells and osteoarthritis: a painful connection. J Clin Invest. 2018;128 (4):1229-1237. doi: 10.1172/JCI95147. PubMed PMID:29608139 PubMed Central PMC5873863.
  31. Guo, Q, Bishop, CJ, Meyer, RA, Wilson, DR, Olasov, L, Schlesinger, DE et al.. Entanglement-Based Thermoplastic Shape Memory Polymeric Particles with Photothermal Actuation for Biomedical Applications. ACS Appl Mater Interfaces. 2018;10 (16):13333-13341. doi: 10.1021/acsami.8b01582. PubMed PMID:29600843 PubMed Central PMC6286191.
  32. Chae, JJ, Shin, YJ, Lee, JD, Seo, K, Elisseeff, JH. Nictitating membrane fixation improves stability of the contact lens on the animal corneal surface. PLoS One. 2018;13 (3):e0194795. doi: 10.1371/journal.pone.0194795. PubMed PMID:29584737 PubMed Central PMC5870980.
  33. Wang, X, Maruotti, J, Majumdar, S, Roman, J, Mao, HQ, Zack, DJ et al.. Collagen vitrigels with low-fibril density enhance human embryonic stem cell-derived retinal pigment epithelial cell maturation. J Tissue Eng Regen Med. 2018;12 (3):821-829. doi: 10.1002/term.2598. PubMed PMID:29049869 .
  34. Beachley, V, Ma, G, Papadimitriou, C, Gibson, M, Corvelli, M, Elisseeff, J et al.. Extracellular matrix particle-glycosaminoglycan composite hydrogels for regenerative medicine applications. J Biomed Mater Res A. 2018;106 (1):147-159. doi: 10.1002/jbm.a.36218. PubMed PMID:28879659 .
  35. Meng, Q, Qin, Y, Deshpande, M, Kashiwabuchi, F, Rodrigues, M, Lu, Q et al.. Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia. Invest Ophthalmol Vis Sci. 2017;58 (11):4514-4523. doi: 10.1167/iovs.17-21974. PubMed PMID:28873177 PubMed Central PMC5584708.
  36. Wang, X, Majumdar, S, Ma, G, Sohn, J, Yiu, SC, Stark, W et al.. Chondroitin Sulfate-Based Biocompatible Crosslinker Restores Corneal Mechanics and Collagen Alignment. Invest Ophthalmol Vis Sci. 2017;58 (10):3887-3895. doi: 10.1167/iovs.16-21292. PubMed PMID:28763562 .
  37. Lu, Q, Yin, H, Grant, MP, Elisseeff, JH. An In Vitro Model for the Ocular Surface and Tear Film System. Sci Rep. 2017;7 (1):6163. doi: 10.1038/s41598-017-06369-8. PubMed PMID:28733649 PubMed Central PMC5522434.
  38. Chung, L, Maestas, DR Jr, Housseau, F, Elisseeff, JH. Key players in the immune response to biomaterial scaffolds for regenerative medicine. Adv Drug Deliv Rev. 2017;114 :184-192. doi: 10.1016/j.addr.2017.07.006. PubMed PMID:28712923 .
  39. Sadtler, K, Sommerfeld, SD, Wolf, MT, Wang, X, Majumdar, S, Chung, L et al.. Proteomic composition and immunomodulatory properties of urinary bladder matrix scaffolds in homeostasis and injury. Semin Immunol. 2017;29 :14-23. doi: 10.1016/j.smim.2017.05.002. PubMed PMID:28583764 PubMed Central PMC8509637.
  40. Jeon, OH, Kim, C, Laberge, RM, Demaria, M, Rathod, S, Vasserot, AP et al.. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med. 2017;23 (6):775-781. doi: 10.1038/nm.4324. PubMed PMID:28436958 PubMed Central PMC5785239.
  41. Lee, D, Lu, Q, Sommerfeld, SD, Chan, A, Menon, NG, Schmidt, TA et al.. Targeted delivery of hyaluronic acid to the ocular surface by a polymer-peptide conjugate system for dry eye disease. Acta Biomater. 2017;55 :163-171. doi: 10.1016/j.actbio.2017.03.043. PubMed PMID:28363785 .
  42. Singh, A, Lee, D, Sopko, N, Matsui, H, Sabnekar, P, Liu, X et al.. Biomanufacturing Seamless Tubular and Hollow Collagen Scaffolds with Unique Design Features and Biomechanical Properties. Adv Healthc Mater. 2017;6 (5):. doi: 10.1002/adhm.201601136. PubMed PMID:28135047 .
  43. Yang, JP, Anderson, AE, McCartney, A, Ory, X, Ma, G, Pappalardo, E et al.. Metabolically Active Three-Dimensional Brown Adipose Tissue Engineered from White Adipose-Derived Stem Cells. Tissue Eng Part A. 2017;23 (7-8):253-262. doi: 10.1089/ten.TEA.2016.0399. PubMed PMID:28073315 PubMed Central PMC5397238.
  44. Green, JJ, Elisseeff, JH. Mimicking biological functionality with polymers for biomedical applications. Nature. 2016;540 (7633):386-394. doi: 10.1038/nature21005. PubMed PMID:27974772 PubMed Central PMC8186828.
  45. Hung, BP, Naved, BA, Nyberg, EL, Dias, M, Holmes, CA, Elisseeff, JH et al.. Three-Dimensional Printing of Bone Extracellular Matrix for Craniofacial Regeneration. ACS Biomater Sci Eng. 2016;2 (10):1806-1816. doi: 10.1021/acsbiomaterials.6b00101. PubMed PMID:27942578 PubMed Central PMC5142751.
  46. Jacobs, HN, Rathod, S, Wolf, MT, Elisseeff, JH. Erratum to: Intra-articular Injection of Urinary Bladder Matrix Reduces Osteoarthritis Development. AAPS J. 2017;19 (2):595. doi: 10.1208/s12248-016-0012-1. PubMed PMID:27844404 .
  47. Jacobs, HN, Rathod, S, Wolf, MT, Elisseeff, JH. Intra-articular Injection of Urinary Bladder Matrix Reduces Osteoarthritis Development. AAPS J. 2017;19 (1):141-149. doi: 10.1208/s12248-016-9999-6. PubMed PMID:27778194 PubMed Central PMC6005649.
  48. Sadtler, K, Allen, BW, Estrellas, K, Housseau, F, Pardoll, DM, Elisseeff, JH et al.. The Scaffold Immune Microenvironment: Biomaterial-Mediated Immune Polarization in Traumatic and Nontraumatic Applications<sup/>. Tissue Eng Part A. 2017;23 (19-20):1044-1053. doi: 10.1089/ten.TEA.2016.0304. PubMed PMID:27736323 PubMed Central PMC6436021.
  49. Romani, WA, Belkoff, SM, Elisseeff, JH. Testosterone may increase rat anterior cruciate ligament strength. Knee. 2016;23 (6):1069-1073. doi: 10.1016/j.knee.2016.07.004. PubMed PMID:27663424 .
  50. Ma, G, Samad, I, Motz, K, Yin, LX, Duvvuri, MV, Ding, D et al.. Metabolic variations in normal and fibrotic human laryngotracheal-derived fibroblasts: A Warburg-like effect. Laryngoscope. 2017;127 (3):E107-E113. doi: 10.1002/lary.26254. PubMed PMID:27585358 PubMed Central PMC5321789.
  51. Jeon, OH, Panicker, LM, Lu, Q, Chae, JJ, Feldman, RA, Elisseeff, JH et al.. Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials. Sci Rep. 2016;6 :26761. doi: 10.1038/srep26761. PubMed PMID:27225733 PubMed Central PMC4881234.
  52. Sadtler, K, Estrellas, K, Allen, BW, Wolf, MT, Fan, H, Tam, AJ et al.. Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells. Science. 2016;352 (6283):366-70. doi: 10.1126/science.aad9272. PubMed PMID:27081073 PubMed Central PMC4866509.
  53. Kim, C, Shores, L, Guo, Q, Aly, A, Jeon, OH, Kim, DH et al.. Electrospun Microfiber Scaffolds with Anti-Inflammatory Tributanoylated N-Acetyl-d-Glucosamine Promote Cartilage Regeneration. Tissue Eng Part A. 2016;22 (7-8):689-97. doi: 10.1089/ten.TEA.2015.0469. PubMed PMID:27019285 PubMed Central PMC4841077.
  54. Sommerfeld, SD, Elisseeff, JH. Time to Relax: Mechanical Stress Release Guides Stem Cell Responses. Cell Stem Cell. 2016;18 (2):166-7. doi: 10.1016/j.stem.2016.01.020. PubMed PMID:26849301 .
  55. Kim, C, Jeon, OH, Kim, DH, Chae, JJ, Shores, L, Bernstein, N et al.. Local delivery of a carbohydrate analog for reducing arthritic inflammation and rebuilding cartilage. Biomaterials. 2016;83 :93-101. doi: 10.1016/j.biomaterials.2015.12.029. PubMed PMID:26773662 PubMed Central PMC8021327.
  56. Lu, Q, Al-Sheikh, O, Elisseeff, JH, Grant, MP. Biomaterials and Tissue Engineering Strategies for Conjunctival Reconstruction and Dry Eye Treatment. Middle East Afr J Ophthalmol. ;22 (4):428-34. doi: 10.4103/0974-9233.167818. PubMed PMID:26692712 PubMed Central PMC4660527.
  57. Jeon, OH, Elisseeff, J. Orthopedic tissue regeneration: cells, scaffolds, and small molecules. Drug Deliv Transl Res. 2016;6 (2):105-20. doi: 10.1007/s13346-015-0266-7. PubMed PMID:26625850 .
  58. Patchan, MW, Chae, JJ, Lee, JD, Calderon-Colon, X, Maranchi, JP, McCally, RL et al.. Evaluation of the biocompatibility of regenerated cellulose hydrogels with high strength and transparency for ocular applications. J Biomater Appl. 2016;30 (7):1049-59. doi: 10.1177/0885328215616273. PubMed PMID:26589295 .
  59. Zhu, AY, Vianna, LM, Borkenstein, EM, Elisseeff, J, Jun, AS. Assessment of a Novel Corneal-Shaping Device With Simultaneous Corneal Collagen Cross-Linking Using a Porcine Eye Model. Cornea. 2016;35 (1):114-21. doi: 10.1097/ICO.0000000000000663. PubMed PMID:26509764 .
  60. Beachley, VZ, Wolf, MT, Sadtler, K, Manda, SS, Jacobs, H, Blatchley, MR et al.. Tissue matrix arrays for high-throughput screening and systems analysis of cell function. Nat Methods. 2015;12 (12):1197-204. doi: 10.1038/nmeth.3619. PubMed PMID:26480475 PubMed Central PMC4666781.
  61. Lin, H, Sun, G, He, H, Botsford, B, Li, M, Elisseeff, JH et al.. Three-Dimensional Culture of Functional Adult Rabbit Lacrimal Gland Epithelial Cells on Decellularized Scaffold. Tissue Eng Part A. 2016;22 (1-2):65-74. doi: 10.1089/ten.TEA.2015.0286. PubMed PMID:26414959 .
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