PUBLICATIONS

  1. Han, J, Rindone, AN, Elisseeff, JH. Immunoengineering Biomaterials for Musculoskeletal Tissue Repair across Lifespan. Adv Mater. 2024; :e2311646. doi: 10.1002/adma.202311646. PubMed PMID:38416061 .
  2. Han, J, Cherry, C, Mejías, JC, Krishnan, K, Ruta, A, Maestas, DR Jr et al.. Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response. Adv Mater. 2023; :e2310476. doi: 10.1002/adma.202310476. PubMed PMID:38087458 .
  3. Yang, B, Rutkowski, N, Elisseeff, J. The foreign body response: emerging cell types and considerations for targeted therapeutics. Biomater Sci. 2023;11 (24):7730-7747. doi: 10.1039/d3bm00629h. PubMed PMID:37904536 .
  4. Chin, AF, Han, J, Clement, CC, Choi, Y, Zhang, H, Browne, M et al.. Senolytic treatment reduces oxidative protein stress in an aging male murine model of post-traumatic osteoarthritis. Aging Cell. 2023;22 (11):e13979. doi: 10.1111/acel.13979. PubMed PMID:37749958 PubMed Central PMC10652304.
  5. Zhang, S, Yuan, L, Danilova, L, Mo, G, Zhu, Q, Deshpande, A et al.. Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence. Genome Med. 2023;15 (1):72. doi: 10.1186/s13073-023-01218-y. PubMed PMID:37723590 PubMed Central PMC10506285.
  6. Walter, LD, Orton, JL, Hannah Fong, EH, Maymi, VI, Rudd, BD, Elisseeff, JH et al.. Single-cell transcriptomic analysis of skeletal muscle regeneration across mouse lifespan identifies altered stem cell states associated with senescence. bioRxiv. 2023; :. doi: 10.1101/2023.05.25.542370. PubMed PMID:37292698 PubMed Central PMC10245980.
  7. Motz, KM, Lina, IA, Samad, I, Murphy, MK, Duvvuri, M, Davis, RJ et al.. Sirolimus-eluting airway stent reduces profibrotic Th17 cells and inhibits laryngotracheal stenosis. JCI Insight. 2023;8 (11):. doi: 10.1172/jci.insight.158456. PubMed PMID:37159282 PubMed Central PMC10393235.
  8. Sommerfeld, SD, Zhou, X, Mejías, JC, Oh, BC, Maestas, DR Jr, Furtmüller, GJ et al.. Biomaterials-based immunomodulation enhances survival of murine vascularized composite allografts. Biomater Sci. 2023;11 (11):4022-4031. doi: 10.1039/d2bm01845d. PubMed PMID:37129566 .
  9. Cherry, C, Andorko, JI, Krishnan, K, Mejías, JC, Nguyen, HH, Stivers, KB et al.. Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies. Geroscience. 2023;45 (4):2559-2587. doi: 10.1007/s11357-023-00785-7. PubMed PMID:37079217 PubMed Central PMC10651581.
  10. Yang, H, Ulge, UY, Quijano-Rubio, A, Bernstein, ZJ, Maestas, DR, Chun, JH et al.. Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds. Nat Chem Biol. 2023;19 (9):1127-1137. doi: 10.1038/s41589-023-01313-6. PubMed PMID:37024727 PubMed Central PMC10697138.
  11. Cottrill, E, Pennington, Z, Wolf, MT, Dirckx, N, Ehresman, J, Perdomo-Pantoja, A et al.. Creation and preclinical evaluation of a novel mussel-inspired, biomimetic, bioactive bone graft scaffold: direct comparison with Infuse bone graft using a rat model of spinal fusion. J Neurosurg Spine. 2023;39 (1):113-121. doi: 10.3171/2023.2.SPINE22936. PubMed PMID:37021767 PubMed Central PMC10758288.
  12. Marquezan, MC, Freitas, D, Majumdar, S, Wang, X, Elisseeff, J, Guyton, DL et al.. Corneal reshaping: an experiment with a type I collagen-based vitrigel for remodeling porcine corneas. Arq Bras Oftalmol. 2023; :. doi: 10.5935/0004-2749.2022-0128. PubMed PMID:36995816 .
  13. Maestas, DR Jr, Chung, L, Han, J, Wang, X, Sommerfeld, SD, Kelly, SH et al.. Helminth egg derivatives as proregenerative immunotherapies. Proc Natl Acad Sci U S A. 2023;120 (8):e2211703120. doi: 10.1073/pnas.2211703120. PubMed PMID:36780522 PubMed Central PMC9974432.
  14. Zhang, S, Yuan, L, Danilova, L, Mo, G, Zhu, Q, Deshpande, A et al.. Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence. bioRxiv. 2023; :. doi: 10.1101/2023.01.10.523481. PubMed PMID:36712023 PubMed Central PMC9882076.
  15. Peña, AN, Sommerfeld, SD, Anderson, AE, Han, J, Maestas, DR Jr, Mejias, JC et al.. Autologous Protein Solution processing alters lymphoid and myeloid cell populations and modulates gene expression dependent on cell type. Arthritis Res Ther. 2022;24 (1):221. doi: 10.1186/s13075-022-02875-x. PubMed PMID:36096945 PubMed Central PMC9465964.
  16. Chin, AF, Elisseeff, JH. Senescent cells in tissue engineering. Curr Opin Biotechnol. 2022;76 :102737. doi: 10.1016/j.copbio.2022.102737. PubMed PMID:35660479 .
  17. Anderson, AE, Wu, I, Parrillo, AJ, Wolf, MT, Maestas, DR Jr, Graham, I et al.. An immunologically active, adipose-derived extracellular matrix biomaterial for soft tissue reconstruction: concept to clinical trial. NPJ Regen Med. 2022;7 (1):6. doi: 10.1038/s41536-021-00197-1. PubMed PMID:35031598 PubMed Central PMC8760240.
  18. Elisseeff, J, Badylak, SF, Boeke, JD. Immune and Genome Engineering as the Future of Transplantable Tissue. N Engl J Med. 2021;385 (26):2451-2462. doi: 10.1056/NEJMra1913421. PubMed PMID:34936741 PubMed Central PMC9009215.
  19. Moore, EM, Maestas, DR Jr, Cherry, CC, Garcia, JA, Comeau, HY, Davenport Huyer, L et al.. Biomaterials direct functional B cell response in a material-specific manner. Sci Adv. 2021;7 (49):eabj5830. doi: 10.1126/sciadv.abj5830. PubMed PMID:34851674 PubMed Central PMC8635437.
  20. Wan, M, Gray-Gaillard, EF, Elisseeff, JH. Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration. Bone Res. 2021;9 (1):41. doi: 10.1038/s41413-021-00164-y. PubMed PMID:34508069 PubMed Central PMC8433460.
  21. Cherry, C, Maestas, DR, Han, J, Andorko, JI, Cahan, P, Fertig, EJ et al.. Computational reconstruction of the signalling networks surrounding implanted biomaterials from single-cell transcriptomics. Nat Biomed Eng. 2021;5 (10):1228-1238. doi: 10.1038/s41551-021-00770-5. PubMed PMID:34341534 PubMed Central PMC9894531.
  22. Wang, X, Chung, L, Hooks, J, Maestas, DR Jr, Lebid, A, Andorko, JI et al.. Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing. Sci Adv. 2021;7 (16):. doi: 10.1126/sciadv.abe2635. PubMed PMID:33863719 PubMed Central PMC8051883.
  23. Tsai, HW, Lina, I, Motz, KM, Chung, L, Ding, D, Murphy, MK et al.. Glutamine Inhibition Reduces Iatrogenic Laryngotracheal Stenosis. Laryngoscope. 2021;131 (7):E2125-E2130. doi: 10.1002/lary.29385. PubMed PMID:33433011 PubMed Central PMC8205976.
  24. Faust, HJ, Zhang, H, Han, J, Wolf, MT, Jeon, OH, Sadtler, K et al.. IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis. J Clin Invest. 2020;130 (10):5493-5507. doi: 10.1172/JCI134091. PubMed PMID:32955487 PubMed Central PMC7524483.
  25. Batshon, G, Elayyan, J, Qiq, O, Reich, E, Ben-Aderet, L, Kandel, L et al.. Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence. Ann Rheum Dis. 2020;79 (10):1370-1380. doi: 10.1136/annrheumdis-2020-217072. PubMed PMID:32665267 PubMed Central PMC7509530.
  26. Moore, EM, Maestas, DR Jr, Comeau, HY, Elisseeff, JH. The Immune System and Its Contribution to Variability in Regenerative Medicine. Tissue Eng Part B Rev. 2021;27 (1):39-47. doi: 10.1089/ten.TEB.2019.0335. PubMed PMID:32635878 PubMed Central PMC7891216.
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  28. Chung, L, Maestas, DR Jr, Lebid, A, Mageau, A, Rosson, GD, Wu, X et al.. Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans. Sci Transl Med. 2020;12 (539):. doi: 10.1126/scitranslmed.aax3799. PubMed PMID:32295900 PubMed Central PMC7219543.
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  30. Tan, Y, Suarez, A, Garza, M, Khan, AA, Elisseeff, J, Coon, D et al.. Human fibroblast-macrophage tissue spheroids demonstrate ratio-dependent fibrotic activity for in vitro fibrogenesis model development. Biomater Sci. 2020;8 (7):1951-1960. doi: 10.1039/c9bm00900k. PubMed PMID:32057054 PubMed Central PMC7179997.
  31. Wolf, MT, Elisseeff, JH. The Canary in the Coal Mine: Biomaterial Implants to Monitor Cancer Recurrence. Cancer Res. 2020;80 (3):377-378. doi: 10.1158/0008-5472.CAN-19-3631. PubMed PMID:32015156 .
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  33. Gabriel, J, Brennan, D, Elisseeff, JH, Beachley, V. Microarray Embedding/Sectioning for Parallel Analysis of 3D Cell Spheroids. Sci Rep. 2019;9 (1):16287. doi: 10.1038/s41598-019-52007-w. PubMed PMID:31705048 PubMed Central PMC6841729.
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