Liam Chung publishes a paper in Science Translational Medicine: IL17 and senescent cells play a role in foreign body response
Liam Chung, a postdoctoral fellow in the Elisseeff Lab, has recently published a paper in Science Translational Medicine. The article, linked below, discusses an immune-mediated response to materials implanted in the body, which can result in a fibrotic capsule around the implant. The role of interleukin 17 (IL17) in this process was examined using a mouse model. Further, senescent cells were found to be a part of the fibrotic response; a senolytic agent (navitoclax) reduced both IL17 and fibrotic response in mice.